Luciano Ferrada

TL;DR: This review will compare the molecular and structural aspects of vitamin C and glucose transporters and their expression in endothelial or choroid plexus cells, which form part of the blood-brain barrier and blood-cerebrospinal fluid (CSF) barrier, respectively and describe SVCT and GLUT expression in different cells of the brain.

TL;DR: DHA is a novel modulator of neuronal energy metabolism by facilitating the utilization of glucose through the PPP for antioxidant purposes by stimulating the rate of lactate uptake by neurons in a time‐ and dose‐dependent manner.

TL;DR: The effects of oxidative stress and DHA uptake on neuronal cell death in vitro indicate that DHA promotes the death of stressed neurons and that astrocytes are essential for the antioxidant defense of neurons, participating in the antioxidative defense of the brain.

TL;DR: It is shown that treatment with AA regulates the expression of pro- and antiapoptotic genes, whereas the oxidation of AA in neurons induces morphological alterations consistent with necroptosis and MLKL activation, suggesting that ne croptosis is a target for cell death induced by vitamin C.

TL;DR: Stable over-expression of SVCT2 in C17.2 cells enhances β III tubulin expression, but it also increases cell death, suggesting that AA transporter levels must be finely tuned during neural stem cell differentiation.