Lucien Bettendorff

TL;DR: A novel finding is the presence of ThTP and AThTP in poorly differentiated fast-growing cells, suggesting a hitherto unsuspected link between these compounds and cell division or differentiation.

TL;DR: Urgent public health responses are warranted in high‐risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamines deficiency in childhood may have lifelong neurodevelopmental consequences.

TL;DR: A demonstration of GABA synthesis and GABAAR function in striatal PSA-NCAM+ cells may shed new light on the understanding of key extrinsic cues that regulate the developmental potential of postnatal neuronal precursors in the CNS.

TL;DR: It is concluded that brain protein and activity levels of α‐ketoglutarate dehydrogenase complex are reduced in patients with AD who have onset after 50 years and suggest that these changes, which are also observed in other human brain disorders, may represent a nonspecific consequence of different neurodegenerative processes.

TL;DR: In animal cells, ThTP can phosphorylate some proteins, but the physiological significance of this mechanism remains unknown, and among the proteins involved in thiamin metabolism, thiam in transporters, Thiamin pyrophosphokinase and a soluble 25‐kDaThiamin triphosphatase have been characterized at the molecular level, in contrast to thiamIn mono‐ and diphosphatases whose specificities remain to be proven.