L
Lui Ng
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 40
Citations - 1290
Lui Ng is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Colorectal cancer & Metastasis. The author has an hindex of 14, co-authored 29 publications receiving 1106 citations. Previous affiliations of Lui Ng include University of Hong Kong.
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Journal ArticleDOI
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
Roberta Pang,Wai Lun Law,Andrew C.Y. Chu,J. T. C. Poon,Colin S.C. Lam,Ariel K.M. Chow,Lui Ng,Leonard Wing-Hong Cheung,Xiao R. Lan,Hui Y. Lan,Victoria P.Y. Tan,Thomas Yau,Ronnie Tung-Ping Poon,Benjamin C. Y. Wong +13 more
TL;DR: A subpopulation of CD26(+) cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis is identified and the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy.
Journal ArticleDOI
Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process.
Wing Lung Yau,Colin S.C. Lam,Lui Ng,Ariel K.M. Chow,Sylvia Tsz Ching Chan,Jacky Yu Ki Chan,Jana Yim Hung Wo,Kevin Tak-Pan Ng,Kwan Man,Ronnie Tung-Ping Poon,Roberta Pang +10 more
TL;DR: The results suggested that miR-106b expression contributed to HCC metastasis by activating the EMT process promoting cell migration in vitro and metastasis in vivo.
Journal ArticleDOI
The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance.
Ariel K.M. Chow,Lui Ng,Colin S.C. Lam,SK Wong,Timothy Ming-Hun Wan,Nathan Shiu Man Cheng,Thomas Yau,Ronnie T.P. Poon,Roberta Pang +8 more
TL;DR: This study suggests that advanced HCC patients with acquired sorafenib resistance may have enhanced tumor growth or distant metastasis, which raises the concern of long-term sorafinib treatment in advanced H CC patients who have developed resistance of sorafanib.
Journal ArticleDOI
Prognostic Significance of CD26 in Patients with Colorectal Cancer
Colin S.C. Lam,Alvin Ho Kwan Cheung,Sunny Kit Man Wong,Timothy Ming-Hun Wan,Lui Ng,Ariel K.M. Chow,Nathan Shiu Man Cheng,Ryan Chung Hei Pak,Hung Sing Li,Johnny Hon Wai Man,Thomas Yau,Oswens Siu-Hung Lo,Jensen T. C. Poon,Roberta Pang,Wai Lun Law +14 more
TL;DR: The expression of CD26 was positively associated with clinicopathological correlation such as TNM staging, degree of differentiation and development of metastasis and may be a useful prognostic marker in patients with CRC.
Journal ArticleDOI
Identification of CD44+ cancer stem cells in human gastric cancer.
Wen-Ji Chen,Xueping Zhang,Chiyuan Chu,Weunghong Leonard Cheung,Lui Ng,Siaochi Lam,Ariel Chow,Tracy Lau,Minhu Chen,Yuyuan Li,Yuqiang Nie,Ben Chenyu Wong,Roberta Pang +12 more
TL;DR: The results demonstrated for the first time the existence of CD44+ cells within the tumors of gastric cancer patients that are endowed with stem cells properties, and provide a plausible explanation for chemo-resistance frequently observed in gastrics cancer patients.