Luisa Muratori

TL;DR: The major inflammatory cytokines involved in Wallerian degeneration and the early phases of nerve regeneration are described and a focus is placed on interleukin-1, interleucin-2,interleuk in-6, tumor necrosis factor-β, InterleukIn-10 and transforming growth factor- β.

TL;DR: The hypothesis that regenerated rat peripheral nerve fibers are able to return spontaneously to their normal pretrauma state, provided there is a sufficiently long recovery time postaxonotmesis, is not supported.

TL;DR: In this paper, a systematic review of mesenchymal stem cells (MSC) for peripheral nerve regeneration after nerve injury is presented. And the characteristics of the most widely used MSCs, their paracrine potential, targeted stimulation, and differentiation potentials into Schwann-like and neuronal-like cells are described.

TL;DR: In vitro assay on primary Schwann cells culture show that VEGF165 stimulation increases Schwann Cells migration, a major process in the promotion of neurite outgrowth, and results obtained by real time polymerase chain reaction showed that V EGF and VEGf family molecules are differentially expressed under regenerating and degenerating condition.

TL;DR: Results demonstrated that SilkBridge™ has an optimized balance of biomechanical and biological properties, being able to sustain a perfect cellular colonization of the conduit and the progressive growth of the regenerating nerve fibers.