L
Lukasz Markiewicz
Researcher at Medical University of Łódź
Publications - 17
Citations - 337
Lukasz Markiewicz is an academic researcher from Medical University of Łódź. The author has contributed to research in topics: DNA repair & Base excision repair. The author has an hindex of 12, co-authored 17 publications receiving 285 citations.
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Journal ArticleDOI
Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease
TL;DR: The findings allow to infer that dysregulated translation, increased expression of BACE1 and ATF4, as a result of eIF2α phosphorylation, may be a major contributor to structural and functional neuronal loss resulting in memory impairment, and blocking PERK-dependent eif2αosphorylation through specific, small-molecule PERK branch inhibitors seems to be a potential treatment strategy for AD individuals.
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Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients.
Lukasz Markiewicz,Dariusz Pytel,Bartosz Mucha,K. Szymanek,Jerzy Szaflik,Jacek P. Szaflik,Ireneusz Majsterek +6 more
TL;DR: The aim of presented work was to analyze the impact of particular polymorphic changes in the promoter regions of the -1607 1G/2G M MP1, -1562 C/T MMP9, -82 A/G MMP12, -511 C/t IL-1β, and 372 T/C TIMP1 genes on their expression level in POAG patients.
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MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study
Tomasz Sliwinski,Karolina Przybyłowska,Lukasz Markiewicz,Pawel Rusin,Wioletta Pietruszewska,Hanna Zelinska-Blizniewska,Jurek Olszewski,Alina Morawiec-Sztandera,Wojciech Młynarski,Ireneusz Majsterek,Ireneusz Majsterek +10 more
TL;DR: The data showed that the Ser326Cys polymorphism of the OGG1 gene may modify the risk of HNSCC associated with smoking, and it was suggested that this polymorphism might be used as predictive factor for head and neck cancer in Polish population.
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Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1β and TIMP1 and the risk of primary open-angle glaucoma.
Lukasz Markiewicz,Ireneusz Majsterek,Karolina Przybyłowska,Lukasz Dziki,Maja Waszczyk,Mira Gacek,Anna Kamińska,Jerzy Szaflik,Jacek P. Szaflik +8 more
TL;DR: The aim of this study was to investigate association of the ‐1607 1G/2G MMP1, ‐the 1562 C/T MMP9, the “82 A/G M MP12,” and the 372 T/C TIMP1 gene polymorphisms with POAG occurrence and to investigate their impact on main clinical features.
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Analysis of oxidative DNA damage and its repair in Polish patients with diabetes mellitus type 2: Role in pathogenesis of diabetic neuropathy
Anna Merecz,Lukasz Markiewicz,Agnieszka Sliwinska,Marcin Kosmalski,Jacek Kasznicki,Józef Drzewoski,Ireneusz Majsterek +6 more
TL;DR: Investigation of DNA damage and repair revealed that T2DM patients have decreased ability to DNA repair, which may be related to oxidative stress connected with BER gene polymorphisms.