L
Luke J. Mappley
Researcher at University of Reading
Publications - 8
Citations - 211
Luke J. Mappley is an academic researcher from University of Reading. The author has contributed to research in topics: Brachyspira pilosicoli & Brachyspira. The author has an hindex of 7, co-authored 8 publications receiving 179 citations. Previous affiliations of Luke J. Mappley include Veterinary Laboratories Agency & Royal Holloway, University of London.
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Journal ArticleDOI
Comparative genomics of Brachyspira pilosicoli strains: genome rearrangements, reductions and correlation of genetic compliment with phenotypic diversity.
Luke J. Mappley,Luke J. Mappley,Michael Black,Michael Black,Manal AbuOun,Alistair C. Darby,Martin J. Woodward,Julian Parkhill,A. Keith Turner,Matthew I. Bellgard,Tom La,Nyree D. Phillips,Roberto M. La Ragione,Roberto M. La Ragione,David J. Hampson,David J. Hampson +15 more
TL;DR: The availability of multiple B. pilosicoli genome sequences has allowed us to demonstrate the substantial genomic variation that exists between these strains, and provides an insight into genetic events that are shaping the species.
Journal ArticleDOI
Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Peter M. Bramley,Roberto M. La Ragione,Roberto M. La Ragione +8 more
TL;DR: It is shown that L. reuteri LM1 mitigates the clinical symptoms of AIS in chickens experimentally challenged with B. pilosicoli and may be a useful tool in the control of A IS.
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Lactobacilli Antagonize the Growth, Motility, and Adherence of Brachyspira pilosicoli: a Potential Intervention against Avian Intestinal Spirochetosis
Luke J. Mappley,Monika A. Tchórzewska,W. A. Cooley,Martin J. Woodward,Roberto M. La Ragione,Roberto M. La Ragione +5 more
TL;DR: Data suggest that motility is essential for B. pilosicoli to adhere to and invade the gut epithelium and that any interference of motility may be a useful tool for the development of control strategies.
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Brachyspira and its role in avian intestinal spirochaetosis.
Luke J. Mappley,Luke J. Mappley,Roberto M. La Ragione,Roberto M. La Ragione,Martin J. Woodward +4 more
TL;DR: Bans on the prophylactic use of antimicrobials in livestock are driving an urgent requirement for alternative treatment strategies for Brachyspira-related diseases, such as AIS, and the potential for the development of tools for genetic manipulation to gain an improved understanding of the pathogenesis.
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Evidence for systemic spread of the potentially zoonotic intestinal spirochaete Brachyspira pilosicoli in experimentally challenged laying chickens.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Roberto M. La Ragione,Roberto M. La Ragione +6 more
TL;DR: A reproducible model of infection in point-of-lay chickens is developed and the virulence of two strains of B. pilosicoli are compared to improve understanding of the mechanisms by which Brachyspira elicit disease in poultry and in testing novel intervention strategies.