Luoyang Wang

TL;DR: Naringenin blocks T GF-β1 trafficking from the trans-Golgi network by suppressing PKC activity, resulting in a reduction of TGF- β1 secretion from breast cancer cells, and suggests that naringen in may be an attractive therapeutic candidate for TGF -β1 related diseases.

TL;DR: The results demonstrated that naringenin could serve as a potent immune-modulator to ameliorate RILI and suggested that a new complementary strategy of maintaining the homeostasis of inflammatory factors combined with radiation could improve the efficacy of thoracic radiotherapy.

TL;DR: The obtained results show that PEG-PE micelle having a hydrophilic nano-cage-like structure in which with a negative charge layer, can capture DTT-induced insulin A and B chains, and block their hydrophobic interaction, thereby preventing aggregation.

TL;DR: In this paper , the authors summarize the mechanisms of nerve damage and pain caused by excessive activation of the NLRP3 inflammasome, which plays an important role in the development of nervous system injury and inflammationrelated diseases.

TL;DR: It was found that antibiotic treatment attenuated the increased infiltration of granulocytes and myeloid cells in colon tissue induced by DSS in female mice, while reducing the proportion of Th17 cells in male mice, which indicated that sex-dependent alterations in the gut microbiota should be considered when applying antibiotics for the treatment of ICI-associated colitis.