Lutz Alder

TL;DR: This overview evaluates the capabilities of mass spectrometry in combination with gas chromatography and liquid chromatography for the determination of a multitude of pesticides and shows a wider scope and better sensitivity if detection is based on LC-MS.

TL;DR: It could be shown that a dilution of extracts by a factor of 25-40 reduces ion suppression to less than 20% if the initial suppression is ≤80%, and for stronger matrix effects or complete elimination of suppression, higher dilution factors were needed.

TL;DR: Of 108 pesticides/metabolites tested, 104 showed sufficient stability in most matrixes for determination by LC/MS/MS, and belong to 20 chemical classes, which demonstrate the general applicability of the method for multiclass analysis.

TL;DR: A new approach for matrix effect compensation in multiresidue analysis was developed in which one single monitor substance is permanently added postcolumn, which may significantly reduce the number of cases in which standard addition is required to confirm violations of maximum residue levels.

TL;DR: Findings are clearly dominated by metabolites of chloroacetanilide herbicides, but metabolites of sulfonylurea and thiocarbamate herbicides and other herbicides together with metabolites of some fungicides were also prominent and correctly predicted to occur in the summary reports of the European pesticide approval process.