Institution
Carl Zeiss AG
Company•Oberkochen, Germany•
About: Carl Zeiss AG is a company organization based out in Oberkochen, Germany. It is known for research contribution in the topics: Lens (optics) & Microscope. The organization has 8197 authors who have published 12647 publications receiving 138899 citations. The organization is also known as: Zeiss.
Papers published on a yearly basis
Papers
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TL;DR: The authors showed that colonisation of mice with a segmented filamentous bacterium (SFB) is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria.
3,860 citations
TL;DR: It is shown that grain boundaries give a significant Raman 'D' peak, impede electrical transport, and induce prominent weak localization indicative of intervalley scattering in graphene, opening a route towards scalable fabrication of single-crystal graphene devices without grain boundaries.
Abstract: Chemical vapour deposition is a promising route for large-scale graphene growth. It is now shown that—through the use of seeds—high-quality, large, single-crystal domains can be grown on a patterned arrangement, and can be used to carefully study the transport across grain boundaries.
1,385 citations
TL;DR: The utility of 7,000 transgenic lines of Drosophila melanogaster for identifying novel neuronal cell types, revealing brain asymmetry, and describing the nature and extent of neuronal shape stereotypy is illustrated.
1,274 citations
TL;DR: The prism coupler, known from experiments on integrated optics, can be used to determine the refractive index and the thickness of a light-guiding thin film by measuring the coupling angles at the prism and fitting them by a theoretical dispersion curve.
Abstract: The prism coupler, known from experiments on integrated optics, can be used to determine the refractive index and the thickness of a light-guiding thin film. Both parameters are obtained simultaneously and with good accuracy by measuring the coupling angles at the prism and fitting them by a theoretical dispersion curve. The fundamentals and limitations. of this method are discussed, its practical use, and mathematical procedures for the evaluation.
996 citations
TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.
Abstract: Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cells. To understand the functional properties of human LS cells, we developed a primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2r gamma(null) mice carrying a complete null mutation of the cytokine gamma c upon the SCID background. Using this model, we demonstrated that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo. They home to and engraft within the osteoblast-rich area of the bone marrow, where AML cells are protected from chemotherapy-induced apoptosis. Quiescence of human LS cells may be a mechanism underlying resistance to cell cycle-dependent cytotoxic therapy. Global transcriptional profiling identified LS cell-specific transcripts that are stable through serial transplantation. These results indicate the potential utility of this AML xenograft model in the development of novel therapeutic strategies targeted at LS cells.
900 citations
Authors
Showing all 8205 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Klaus Weber | 121 | 524 | 60346 |
| Andreas Voss | 83 | 757 | 28426 |
| Ernst H. K. Stelzer | 71 | 280 | 24611 |
| Daniel A. Fischer | 70 | 411 | 17619 |
| Danielle J Harvey | 69 | 210 | 22258 |
| Chris A. Johnson | 69 | 383 | 21532 |
| Volker Hessel | 68 | 572 | 21707 |
| Erik L. Ritman | 67 | 408 | 14847 |
| Michael Gleeson | 65 | 234 | 17603 |
| Malvin C. Teich | 64 | 410 | 19431 |
| Frederik Wenz | 60 | 468 | 14245 |
| Christian Koos | 57 | 451 | 14541 |
| Georg Pohnert | 53 | 276 | 9362 |
| John T. Fourkas | 51 | 260 | 8197 |
| Armin G. Aberle | 49 | 449 | 11386 |