L
Luyu Zhang
Researcher at Chongqing Medical University
Publications - 17
Citations - 738
Luyu Zhang is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Signal transduction & microRNA. The author has an hindex of 9, co-authored 17 publications receiving 381 citations.
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Journal ArticleDOI
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
Xiaying Zheng,Mengge Huang,Lei Xing,Rui Yang,Xiaosong Wang,Rong Jiang,Luyu Zhang,Junxia Chen +7 more
TL;DR: Investigation of the expression pattern of circRNAs in four pairs of TNBC tissues and paracancerous normal tissues revealed that circSEPT9 could regulate the expression of Leukemia Inhibitory Factor (LIF) via sponging miR-637 and activate LIF/Stat3 signaling pathway involved in progression of T NBC.
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LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.
Hong Yi,Rui Peng,Luyu Zhang,Yan Sun,Huimin Peng,Handeng Liu,Li-juan Yu,Ailing Li,Yajuan Zhang,Wen-hao Jiang,Zheng Zhang +10 more
TL;DR: Results suggest lincRNA-Gm4419 may participate in the inflammation, fibrosis and proliferation in MCs under high-glucose condition through NF-κB/NLRP3 inflammasome signaling pathway, and may provide new insights into the regulation of Gm 4419 during the progression of DN.
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Long non-coding RNA Rpph1 promotes inflammation and proliferation of mesangial cells in diabetic nephropathy via an interaction with Gal-3.
TL;DR: Seven DN-related lncRNAs are identified using RNA-sequencing and one lncRNA in particular, Rpph1 (ribonuclease P RNA component H1), exhibited significantly increased expression and was found to regulate cell proliferation and the expression of inflammatory cytokines in mesangial cells.
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Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1.
Rui Peng,Handeng Liu,Huimin Peng,Ji Zhou,He Zha,Xin Chen,Luyu Zhang,Yan Sun,Pin Yin,Li Wen,Tianhui Wu,Zheng Zhang +11 more
TL;DR: It is concluded that promoter hypermethylation and down-expression of let-7a-3 may play a role in DN by targeting UHRF1.
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Comprehensive Analysis of Differentially Expressed Profiles of lncRNAs/mRNAs and miRNAs with Associated ceRNA Networks in Triple-Negative Breast Cancer.
TL;DR: Novel lncRNAs/miRNAs which may serve as potential biomarkers to predict the survival and therapeutic targets for TNBC patients based on a large-scale sample are identified.