L
Lynn J. Buchanan
Publications - 1
Citations - 759
Lynn J. Buchanan is an academic researcher. The author has contributed to research in topics: Acute toxicity & Toxicity. The author has an hindex of 1, co-authored 1 publications receiving 701 citations.
Papers
More filters
Journal ArticleDOI
Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production
John P. Leonard,Matthew L. Sherman,Gerald L. Fisher,Lynn J. Buchanan,Glenn R. Larsen,Michael B. Atkins,Jeffrey A. Sosman,Janice P. Dutcher,Nicholas J. Vogelzang,John L. Ryan +9 more
TL;DR: It is determined that a single injection of rhIL-12 2 weeks before consecutive dosing included in the Phase 1 study, but not in the schedule of administration in thephase 2 study, has a profound abrogating effect on IL-12–induced interferon-γ (IFN-γ) production and toxicity.