L
Lynsey Vaughan
Researcher at Institute of Cancer Research
Publications - 7
Citations - 290
Lynsey Vaughan is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Neuroblastoma & N-Myc. The author has an hindex of 6, co-authored 7 publications receiving 251 citations. Previous affiliations of Lynsey Vaughan include University of Manchester.
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Journal ArticleDOI
The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo
Amir Faisal,Lynsey Vaughan,Vassilios Bavetsias,Chongbo Sun,Butrus Atrash,Sian Avery,Yann Jamin,Simon P. Robinson,Paul Workman,Julian Blagg,Florence I. Raynaud,Suzanne A. Eccles,Louis Chesler,Spiros Linardopoulos +13 more
TL;DR: The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN-amplified neuroblastoma and exhibits antiproliferative activity against a wide range of human solid tumor cell lines.
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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Kevin Myant,Patrizia Cammareri,Michael C. Hodder,Jimi Wills,Alex von Kriegsheim,Balázs Győrffy,Mamunur Rashid,Simona Polo,Elena Maspero,Lynsey Vaughan,Basanta Gurung,Evan Barry,Angeliki Malliri,Fernando D. Camargo,David J. Adams,Antonio Iavarone,Anna Lasorella,Owen J. Sansom +17 more
TL;DR: HUwe1 is identified as a bona fide tumour suppressor gene in the intestinal epithelium and a potential vulnerability of HUWE1‐mutated tumours to DNA‐damaging agents and inhibitors of anti‐apoptotic proteins is suggested.
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HUWE1 ubiquitylates and degrades the Rac activator TIAM1 promoting cell–cell adhesion disassembly, migration and invasion
Lynsey Vaughan,Chong Teik Tan,Anna Chapman,Daisuke Nonaka,Natalie A. Mack,Duncan L. Smith,Richard Booton,Adam Hurlstone,Angeliki Malliri +8 more
TL;DR: A critical role for HUWE1 is elucidated in regulating epithelial cell-cell adhesion and additional evidence that ubiquitylation contributes to spatiotemporal control of RAC is provided.
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Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors
Lynsey Vaughan,Lynsey Vaughan,Paul A. Clarke,Karen Barker,Yvan Chanthery,Clay Gustafson,Elizabeth R. Tucker,Jane Renshaw,Florence I. Raynaud,Xiaodun Li,Xiaodun Li,Rosemary Burke,Yann Jamin,Simon P. Robinson,Andrew D.J. Pearson,Michel Maira,William A. Weiss,Paul Workman,Louis Chesler,Louis Chesler +19 more
TL;DR: It is established that MYCN expression is a marker indicative of likely clinical sensitivity to mTOR inhibition, and a rationale for the selection of clinical candidate MyCN-destabilizers likely to be useful for the treatment of MYCN-driven cancers is provided.
Journal ArticleDOI
Evaluation of Clinically Translatable MR Imaging Biomarkers of Therapeutic Response in the TH-MYCN Transgenic Mouse Model of Neuroblastoma
Yann Jamin,Elizabeth R. Tucker,Evon Poon,Sergey V. Popov,Lynsey Vaughan,Jessica K.R. Boult,Hannah Webber,Albert Hallsworth,Lauren C.J. Baker,Chris Jones,Dow-Mu Koh,Andrew D.J. Pearson,Louis Chesler,Simon P. Robinson +13 more
TL;DR: The T1 relaxation time is a robust noninvasive imaging biomarker of response to therapy in tumors in TH-MYCN mice, which emulate high-risk neuroblastoma in children.