M
M. Angeles Cabello
Researcher at Merck & Co.
Publications - 11
Citations - 548
M. Angeles Cabello is an academic researcher from Merck & Co.. The author has contributed to research in topics: Melanocortin receptor & Receptor. The author has an hindex of 9, co-authored 11 publications receiving 514 citations.
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Journal ArticleDOI
Screening of basidiomycetes for antimicrobial activities.
Inmaculada Suay,F. Arenal,F.J. Asensio,Angela Basilio,M. Angeles Cabello,M. Teresa Díez,Juan B. García,Antonio González del Val,Julian Gorrochategui,Pilar Hernandez,Fernando Pelaez,M. Francisca Vicente +11 more
TL;DR: Isolates from some species showed large differences in their ability to produce metabolites with antimicrobial activity, possibly reflecting genetic differences at the infraspecific level.
Journal ArticleDOI
The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity.
Suzanne M. Mandala,Rosemary A. Thornton,Beth R. Frommer,James E. Curotto,Walter Rozdilsky,Myra B. Kurtz,Robert A. Giacobbe,Gerald F. Bills,M. Angeles Cabello,Isabel Martin,Fernando Pelaez,Guy H. Harris +11 more
TL;DR: Australifungin exhibited broad spectrum antifungal activity against human pathogenic fungi with MICs against Candida spp.
Journal ArticleDOI
Inhibition of serine palmitoyl-transferase activity by lipoxamycin.
Suzanne M. Mandala,Beth R. Frommer,Rosemary A. Thornton,Mrya B. Kurtz,Noel M. Young,M. Angeles Cabello,Olga Genilloud,Jerrold M. Liesch,Jack L. Smith,Wendy S. Horn +9 more
TL;DR: The sphingofungins resemble the long chain base intermediates in the sphingolipid pathway and inhibit the serine palmitoyltransferase at the nanomolar level.
Journal ArticleDOI
Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms.
M. Angeles Cabello,Gonzalo Platas,Javier Collado,M. Teresa Díez,Isabel Martin,Francisca Vicente,Maria S. Meinz,Janet C. Onishi,Cameron M. Douglas,John R. Thompson,Myra B. Kurtz,Robert E. Schwartz,Gerald F. Bills,Robert A. Giacobbe,George K. Abruzzo,Amy M. Flattery,Li Kong,Fernando Pelaez +17 more
TL;DR: A novel acidic steroid, named arundifungin, was purified from a fungal extract obtained from a liquid culture of Arthrinium arundinis collected in Costa Rica, and its antifungal spectrum was comparable to those of echinocandins and papulacandins, preferentially inhibiting the growth of Candida and Aspergillus strains, with very poor activity against Cryptococcus.
Journal ArticleDOI
Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.
Maria A. Bednarek,Tanya MacNeil,Rui Tang,Tung M. Fong,M. Angeles Cabello,Marta Maroto,Ana Teran +6 more
TL;DR: In this article, cyclic peptides derived from MTII, Ac-Nle-cyclo(Asp-His6-D-Phe7-Arg8-Trp-Lys)-NH2 (a pan-agonist at the melanocortin receptors) were prepared and tested in binding and functional assays on CHO cells expressing hMC1b,3-5R.