R
Rui Tang
Researcher at Merck & Co.
Publications - 29
Citations - 1136
Rui Tang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Melanocortin & Agonist. The author has an hindex of 15, co-authored 28 publications receiving 1100 citations.
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Journal ArticleDOI
A role for the melanocortin 4 receptor in sexual function.
Lex H.T. Van der Ploeg,William J. Martin,Andrew D. Howard,Ravi P. Nargund,Christopher P. Austin,Xiao-Ming Guan,Jennifer E. Drisko,Doreen E. Cashen,Iyassu K. Sebhat,Arthur A. Patchett,David J. Figueroa,Anthony G. DiLella,Brett Connolly,David H. Weinberg,Carina P. Tan,Oksana C. Palyha,Sheng-Shung Pong,Tanya MacNeil,Charles Rosenblum,Aurawan Vongs,Rui Tang,Hong Yu,Andreas W. Sailer,Tung Ming Fong,Cathy R.-R.C. Huang,Michael R. Tota,R. S. L. Chang,Ralph A. Stearns,Constantin Tamvakopoulos,George J. Christ,Deborah L. Drazen,Brian D. Spar,Randy J. Nelson,D. Euan MacIntyre +33 more
TL;DR: It is shown that the melanocortin 4 receptor, implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior, and evidence is provided that MC4R-mediated proerectile responses may be activated through neuronal circuitry in spinal cord erectile centers and somatosensory afferent nerve terminals of the penis.
Journal ArticleDOI
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.
Iyassu K. Sebhat,William J. Martin,Zhixiong Ye,Khaled Barakat,Ralph T. Mosley,David B. R. Johnston,Raman K. Bakshi,Palucki Brenda,David H. Weinberg,Tanya MacNeil,Rubana N. Kalyani,Rui Tang,Ralph A. Stearns,Randy R. Miller,Constantin Tamvakopoulos,Alison M. Strack,Erin McGowan,Doreen E. Cashen,Jennifer E. Drisko,Gary J Hom,Andrew D. Howard,D. Euan MacIntyre,Lex H.T. Van der Ploeg,and Arthur A. Patchett,Ravi P. Nargund +24 more
TL;DR: 1, a potent, selective, small-molecule agonist of the MC4 receptor, is reported, which confirms the food intake lowering effects of MC4R agonism and suggests another role for the receptor in the stimulation of erectile activity.
Journal ArticleDOI
Selective, High Affinity Peptide Antagonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro†
Maria A. Bednarek,Tanya MacNeil,Rubana N. Kalyani,Rui Tang,Lex H.T. Van der Ploeg,David H. Weinberg +5 more
TL;DR: Examination of the sequences of these new peptides revealed that the D-(2')Nal(7)-Arg(8)-Trp(9) segment of peptide 1 forms the "essential core" required for high affinity and high selectivity of analogues of peptides of compound 1 at hMC-4R.
Journal ArticleDOI
Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5
Maria A. Bednarek,Tanya MacNeil,Rubana N. Kalyani,Rui Tang,Lex H.T. Van der Ploeg,David H. Weinberg +5 more
TL;DR: Proline-substituted analogs of MTII, a potent nonselective agonist at melanocortin receptors, were prepared by solid-phase syntheses and evaluated for their ability to bind and activate human MC-3, MC-4, and MC-5 receptors and it was demonstrated that the N-terminal fragment ofMTII has virtually no effect on the binding affinity and activation at hMC-4R, but it is essential for full potency at h MC
Journal ArticleDOI
Potent and selective peptide agonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.
Maria A. Bednarek,Tanya MacNeil,Rui Tang,Rubana N. Kalyani,Lex H.T. Van der Ploeg,David H. Weinberg +5 more
TL;DR: The cyclic derivatives of alphaMSH of a general structure, cyclo(X-His-d-Phe-Arg-Trp-Y)-NH(2), where X is succinic acid or an omega-amino-carboxylic acid, and Y is an alpha,omega-di-aminos-car boxylic Acid, turned out to be potent and receptor-specific agonists at melanocortin receptors 3 and 5.