Robert A. Giacobbe

TL;DR: Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.

TL;DR: The minimal effective concentration end point, defined as the lowest caspofungin concentration yielding conspicuously aberrant hyphal growth, gave excellent reproducibility for data from 14 of the 17 participating laboratories, and the best interlaboratory separation of Candida isolates of known high and low susceptibility to casp ofungin.

TL;DR: Australifungin exhibited broad spectrum antifungal activity against human pathogenic fungi with MICs against Candida spp.

TL;DR: In this paper, a new triterpene glycoside, called Caspofungin acetate (CFA), was detected in a culture belonging to the form-genus Hormonema, isolated from leaves of Juniperus communis.

TL;DR: A new lipopeptide antifungal agent, similar to echinocandin B, has been isolated from Zalerion arboricola and studies indicate that L-671,329 is produced under both solid and liquid fermentation conditions.