M
M.B.E. Sweet
Researcher at University of the Witwatersrand
Publications - 9
Citations - 606
M.B.E. Sweet is an academic researcher from University of the Witwatersrand. The author has contributed to research in topics: Proteoglycan & Chondroitin sulfate. The author has an hindex of 9, co-authored 9 publications receiving 586 citations.
Papers
More filters
Journal ArticleDOI
Biochemical changes in intervertebral disc degeneration
TL;DR: It is suggested that a large proportion of proteoglycans from normal disc have undergone a degree of degradation in the hyaluronate binding region and that proteoglycan synthesis in this tissue is slower than in degenerate tissue.
Journal ArticleDOI
Age-related changes in proteoglycan structure
TL;DR: Proteoglycans of calf and steer articular cartilage were studied with a view of assessing structure and changes occurring as a result of the aging process and showed a maturation-related decrease in chondroitin sulfate content and an enrichment in keratan sulfate chains in both the chondrodynamically larger and smaller keratan sulphate-rich regions.
Journal ArticleDOI
Maturation-related changes in proteoglycans of fetal articular cartilage.
E.J.-M.A. Thonar,M.B.E. Sweet +1 more
TL;DR: A major increase in the absolute number of glycosaminoglycans and oligosaccharides attached to core protein was detected during the third trimester of fetal life and no further changes in substitution occurred in early postnatal life.
Journal ArticleDOI
Regional distribution of water and glycosaminoglycan in immature articular cartilage.
TL;DR: The results suggest that some keratan sulphate may be synthesized as a reaction to load in bovine immature articular cartilage as well as in the growing zone.
Journal ArticleDOI
Anatomically determined polydispersity of proteoglycans of immature articular cartilage
TL;DR: It is suggested that age-related maturation may be modified by physiological load or stress in calf articular cartilage.