M
M. B. O'hara
Researcher at Merck & Co.
Publications - 2
Citations - 773
M. B. O'hara is an academic researcher from Merck & Co.. The author has contributed to research in topics: Peptide sequence & Farnesyltransferase. The author has an hindex of 2, co-authored 2 publications receiving 755 citations.
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Journal ArticleDOI
Sequence dependence of protein isoprenylation
S L Moores,Michael D. Schaber,Scott D. Mosser,Elaine Rands,M. B. O'hara,Victor M. Garsky,Mark S. Marshall,David L. Pompliano,Jackson B. Gibbs +8 more
TL;DR: Three different isoprenyl-protein transferases are identified that are each selective for theirIsoprenoid and protein substrates, and a leucine residue at the C terminus influenced whether a CAAX protein was either farnesylated or geranylgeranylated preferentially.
Journal ArticleDOI
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.
Michael D. Schaber,M. B. O'hara,Victor M. Garsky,Scott D. Mosser,James D. Bergstrom,S L Moores,Mark S. Marshall,Paul A. Friedman,Richard A. F. Dixon,Jackson B. Gibbs +9 more
TL;DR: In this article, Farnesyl-PPi was used as a precursor and Escherichia coli-expressed Ras was radiolabeled upon incubation with the cytosolic fraction of bovine brain.