Advanced Statistical Methods in Biometric Research.

Tea polyphenols for health promotion

time, probably by stimulation of the hepatic microsomal enzyme system3. Similar properties were exhibited by its roots. However, the petroleum ether extract (PEE) of the roots enhanced pentobarbitone sleeping time, probably due to CNS depression4. The PEE of the seed of Pongomia pinnata was further tested for nootropic activity in an experimental model of Alzheimer’s disease (created by ibotenic acid induced lesioning of nuclear basalis magnocellularis). It reversed both, the cognitive deficits and the reduction in cholinergic markers after 2 weeks of treatment. Reversal of perturbed cholinergic function appears to be the possible mechanism5.

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Pharmacology of medicinal plants and natural products

Important progress has been made in the past five years concerning the effects of green and black tea on health. Experimentation with new accurate tools provide useful information about the metabolism of tea components in the body, their mode of action as antioxidants at the cellular level and their protective role in the development of cancer, cardiovascular disease and other pathologies. The use of tea components as nutraceuticals and functional foods are also discussed.

A review of latest research findings on the health promotion properties of tea

Presynaptic modulation of neurochemical transmission.

The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model in Balb-C mice. Intra-peritoneal administration of the alcohol extract of the seed both before and after inoculation of EAC cell in mice produced more than 70% inhibition of tumour cell growth with respect to the control. Treatment with the extract was found to enhance both the peritoneal exudate cell and macrophage cell counts. The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract.

Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.

Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation. 2 The paralytic effect of oxotremorine was absent when the diaphragm was stimulated directly in the presence of hemicholinium-3 (0.42 mM), at a time when twitch responses to indirect stimulation ceased completely. 3 Oxotremorine, at two different pharmacologically active doses, strikingly increased the resting as well as electrically evoked release of acetylcholine into the bathing fluid from the phrenic nerve-diaphragm preparation. 4 This presynaptic effect of oxotremorine may explain its pharmacological effects at the cholinergic synapses studied so far.

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1978.tb08445.x

Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.

Effect of green tea (Camellia sinensis) extract on the rat diaphragm

Investigations were carried out to evaluate the effect of acute and chronic administration of both black and green tea on three models of experimentally induced convulsions in mice. Tea extract (both black and green) significantly accelerated the onset of convulsion, increased the duration of convulsion and mortality in mice. Since both the extracts failed to alter the GABA level in brain, based on the earlier report that both black and green tea might act on Ca 2+ channels, it can be suggested that the observed proconvulsive effect of tea is not mediated through GABA but through Ca 2+ channels.

Proconvulsive effect of tea (Camellia sinensis) in mice.

Objective: Megaloblastosis (i.e., megaloblastic transformation of erythroid precursor cells in the bone marrow) is the cytomorphological hallmark of megaloblastic anemia resulting f

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M. Das

Papers

Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.

Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.

Effect of green tea (Camellia sinensis) extract on the rat diaphragm

Proconvulsive effect of tea (Camellia sinensis) in mice.

Megaloblastosis: from morphos to molecules.