M
M De Mol
Researcher at Katholieke Universiteit Leuven
Publications - 16
Citations - 1690
M De Mol is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Plasminogen activator & Plasminogen activator inhibitor-1. The author has an hindex of 13, co-authored 16 publications receiving 1670 citations. Previous affiliations of M De Mol include Veterans Health Administration & Cleveland Clinic.
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Journal ArticleDOI
Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).
Paul Declerck,M De Mol,Marie-Christine Alessi,S Baudner,E P Pâques,Klaus T. Preissner,G Müller-Berghaus,Desire Collen +7 more
TL;DR: The gel filtration behavior, mobility on sodium dodecyl sulfate-gel electrophoresis, and concentration in plasma suggest that PAI-1-BP is a multimer (presumably a dimer) of S protein accounting for approximately 35% of the S protein in plasma.
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Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.
Peter Carmeliet,Jm Stassen,Luc Schoonjans,Beverly Ream,J J van den Oord,M De Mol,Richard C. Mulligan,D. Collen +7 more
TL;DR: Disruption of the PAI-1 gene in mice appears to induce a mild hyperfibrinolytic state and a greater resistance to venous thrombosis but not to impair hemostasis.
Journal Article
Vascular wound healing and neointima formation induced by perivascular electric injury in mice.
Peter Carmeliet,Lieve Moons,Jm Stassen,M De Mol,Ann Bouché,J. J. Van Den Oord,Mark M. Kockx,D. Collen +7 more
TL;DR: Electric injury of arteries provides a model of vascular wound healing with arterial neointima formation and re-endothelialization that may be useful for the genetic analysis of its molecular mechanisms in transgenic mice.
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Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator.
TL;DR: Fluorescence spectroscopy revealed conformational differences between the latent, active, and substrate forms of PAI-1, confirming the hypothesis that PAi-1 may occur in three interconvertible conformations: latent, inhibitor, and substrates.
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Fibrinolytic response and fibrin fragment D-dimer levels in patients with deep vein thrombosis.
TL;DR: The combined assays of total and free t-PA antigen and of fragment D-dimer may be useful for the evaluation of the dynamics of the fibrinolytic system in physiological and pathological conditions.