D
D. Collen
Researcher at Katholieke Universiteit Leuven
Publications - 281
Citations - 16708
D. Collen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Plasminogen activator & Plasmin. The author has an hindex of 68, co-authored 281 publications receiving 16471 citations. Previous affiliations of D. Collen include Kindai University & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
TL;DR: The kinetic analysis suggested that the activation in the presence of fibrin occurs through binding of an activator molecule to the clot surface and subsequent addition of plasminogen (sequential ordered mechanism) to form a cyclic ternary complex.
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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
Khalid Bajou,Agnès Noël,Robert D. Gerard,Véronique Masson,Nils Brünner,Claus Holst-Hansen,Mihaela Skobe,Norbert E. Fusenig,Peter Carmeliet,D. Collen,Jean-Michel Foidart +10 more
TL;DR: It is reported here that deficient PAI1 expression in host mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes and this experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis.
Journal Article
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998)
P Carmeliet,Yuval Dor,Jean-Marc Herbert,Dai Fukumura,Koenraad Brusselmans,Mieke Dewerchin,Michal Neeman,Françoise Bono,Rinat Abramovitch,Patrick H. Maxwell,Cameron J. Koch,Peter J. Ratcliffe,Lieve Moons,Rakesh K. Jain,D. Collen,Eli Keshert +15 more
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Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.
Peter Carmeliet,Jm Stassen,Luc Schoonjans,Beverly Ream,J J van den Oord,M De Mol,Richard C. Mulligan,D. Collen +7 more
TL;DR: Disruption of the PAI-1 gene in mice appears to induce a mild hyperfibrinolytic state and a greater resistance to venous thrombosis but not to impair hemostasis.
Journal ArticleDOI
Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways
Yan-You Huang,Mary Elizabeth Bach,Hans-Peter Lipp,Min Zhuo,David P. Wolfer,Robert D. Hawkins,Luc Schoonjans,Eric R. Kandel,Jean-Marie Godfraind,Richard C. Mulligan,D. Collen,Peter Carmeliet +11 more
TL;DR: Genetic evidence is provided that t-PA is a downstream effector gene important for L-LTP and that modest impairment of L- LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes.