L
Luc Schoonjans
Researcher at Katholieke Universiteit Leuven
Publications - 67
Citations - 9651
Luc Schoonjans is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 33, co-authored 64 publications receiving 7770 citations. Previous affiliations of Luc Schoonjans include Sun Yat-sen University & Heidelberg University.
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Journal ArticleDOI
Physiological consequences of loss of plasminogen activator gene function in mice.
Peter Carmeliet,Peter Carmeliet,Luc Schoonjans,Lena Kieckens,Beverly Ream,Jay L. Degen,Roderick T. Bronson,Rita Vos,Joost van den Oord,Desire Collen,Richard C. Mulligan +10 more
TL;DR: Direct evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes.
Journal ArticleDOI
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
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A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Karel De Gendt,Johannes V. Swinnen,Philippa T. K. Saunders,Luc Schoonjans,Mieke Dewerchin,Ann Devos,Karen Tan,Nina Atanassova,Frank Claessens,Charlotte Lécureuil,Walter Heyns,Peter Carmeliet,Florian Guillou,Richard M. Sharpe,Guido Verhoeven +14 more
TL;DR: It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that sPermatocyte/spermatid development/survival critically depends on androgens.
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Joanna Kalucka,Laura P.M.H. de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J. Dumas,Elda Meta,Nadine V. Conchinha,Federico Taverna,Laure-Anne Teuwen,Koen Veys,Melissa García-Caballero,Shawez Khan,Vincent Geldhof,Liliana Sokol,Rongyuan Chen,Lucas Treps,Mila Borri,Pauline de Zeeuw,Charlotte Dubois,Tobias K. Karakach,Kim D. Falkenberg,Magdalena Parys,Xiangke Yin,Stefan Vinckier,Yuxiang Du,Robert A. Fenton,Luc Schoonjans,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Bernard Thienpont,Lin Lin,Lars Bolund,Xuri Li,Yonglun Luo,Peter Carmeliet,Peter Carmeliet +36 more
TL;DR: An atlas of >32,000 single-EC transcriptomes from 11 mouse tissues was constructed and 78 EC subclusters were identified, including Aqp7+ intestinal capillaries and angiogenic ECs in healthy tissues and provides a powerful discovery tool and resource value.
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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
TL;DR: The question of how proteins such as the β-amyloid precursor protein (β-APP), Notch-1 and others can be cleaved in the plane of the membrane has challenged cell biologists and researchers into Alzheimer’s disease for some time and γ-secretase activity is considered an important therapeutic target.