M
M. Di Domenico
Publications - 14
Citations - 1712
M. Di Domenico is an academic researcher. The author has contributed to research in topics: Receptor & Tyrosine kinase. The author has an hindex of 11, co-authored 14 publications receiving 1688 citations.
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Journal ArticleDOI
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.
Anna Rita Migliaccio,M. Di Domenico,Gabriella Castoria,A. de Falco,Paola Bontempo,E. Nola,Ferdinando Auricchio +6 more
TL;DR: Estradiol activates the tyrosine kinase/p21ras/MAP‐kinase pathway in MCF‐7 cells with kinetics which are similar to those of peptide mitogens and this finding proves that the classic estradiol receptor is responsible for the transduction pathway activation.
Journal Article
Estradiol Activation of Human Colon Carcinoma-derived Caco-2 Cell Growth
M. Di Domenico,Gabriella Castoria,Antonio Bilancio,Anna Rita Migliaccio,Ferdinando Auricchio +4 more
TL;DR: Findings show that in subconfluent Caco-2 cells, the estradiol-receptor complex activates the c-src, c-yes/MAP kinase pathway and activates growth, which could have important implications for the understanding of human intestinal carcinogenesis.
Journal ArticleDOI
Phosphorylation on tyrosine of in vitro synthesized human estrogen receptor activates its hormone binding.
Antimo Migliaccio,M. Di Domenico,S. Green,A. de Falco,E. L. Kajtaniak,Francesco Blasi,Pierre Chambon,Ferdinando Auricchio +7 more
TL;DR: It is reported that phosphorylation on tyrosine of the synthetic receptor by an extensively purified calf uterus kinase increases hormone binding towards maximal levels without change in affinity.
Journal ArticleDOI
Sex steroid hormones act as growth factors.
Anna Rita Migliaccio,Gabriella Castoria,M. Di Domenico,A. de Falco,Antonio Bilancio,Maria Lombardi,Daniela Bottero,Lilian Varricchio,Merlin Nanayakkara,A. Rotondi,Ferdinando Auricchio +10 more
TL;DR: A novel reciprocal cross-talk between the two pathways appears to be mediated by the ER, and in all tested cells, activation of the signalling pathways has a proliferative role.
Journal ArticleDOI
Properties of a purified estradiol-dependent calf uterus tyrosine kinase
Gabriella Castoria,Anna Rita Migliaccio,S. Green,M. Di Domenico,Pierre Chambon,Ferdinando Auricchio +5 more
TL;DR: Findings indicate that this kinase, unlike other tyrosine kinases, phosphorylates tyrosyl residues with acidic amino acids close to the carboxyl side, and proves a causal relationship between the phosphorylation of estradiol receptor on tyrosin 537 and its hormone binding activity.