Paola Bontempo

TL;DR: Estradiol activates the tyrosine kinase/p21ras/MAP‐kinase pathway in MCF‐7 cells with kinetics which are similar to those of peptide mitogens and this finding proves that the classic estradiol receptor is responsible for the transduction pathway activation.

TL;DR: It is reported that HDACIs induce, in addition to p21, expression of TRAIL by directly activating the TNFSF10 promoter, thereby triggering tumor-selective death signaling in acute myeloid leukemia (AML) cells and the blasts of individuals with AML.

TL;DR: It is reported here that the Feijoa acetonic extract exerts anti-cancer activities on solid and hematological cancer cells and shows a tumor-selective activity, supporting the hypothesis of its epigenetic pro-apoptotic regulation in cancer systems.

TL;DR: The results indicate that Xanthoria parietina is a major potential source of antimicrobial and anticancer substances.

TL;DR: Co-immunoprecipitation experiments in cell extract from cultured cells or target tissues indicated that estrogen receptor was complexed with the retinoblastoma binding protein RIZ in a ligand-dependent manner, presumably involved in proliferation control.