M
M G Caron
Researcher at Duke University
Publications - 18
Citations - 2242
M G Caron is an academic researcher from Duke University. The author has contributed to research in topics: Receptor & Adenylate kinase. The author has an hindex of 12, co-authored 18 publications receiving 2228 citations.
Papers
More filters
Journal ArticleDOI
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation
Journal ArticleDOI
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
L. M.F. Leeb-Lundberg,Susanna Cotecchia,Jon W. Lomasney,J. F. Debernardis,Robert J. Lefkowitz,M G Caron +5 more
TL;DR: Results indicate that calcium- and phospholipid-dependent protein kinase may play an important role in regulating the function of receptors that are coupled to the inositol phospholIPid cycle by phosphorylating and deactivating them.
Journal ArticleDOI
Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.
J. L. Benovic,L J Pike,R A Cerione,C Staniszewski,T Yoshimasa,Juan Codina,M G Caron,Robert J. Lefkowitz +7 more
TL;DR: The quantitative extent of receptor phosphorylation and functional impairment are virtually identical to those previously observed when intact turkey erythrocytes were incubated with cyclic AMP.
Journal ArticleDOI
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
R A Cerione,C Staniszewski,J. L. Benovic,Robert J. Lefkowitz,M G Caron,Peter Gierschik,Robert L. Somers,Allen M. Spiegel,Juan Codina,Lutz Birnbaumer +9 more
TL;DR: The functional interactions of two pure receptor proteins with three different pure guanine nucleotide regulatory proteins in phosphatidylcholine vesicles suggest that the different nucleotide regulators are capable of a common upper limit of catalytic efficiency which can best be attained when coupled to the appropriate receptor.
Journal ArticleDOI
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.
Madan M. Kwatra,Debra A. Schwinn,J. Schreurs,Jonathan L. Blank,C.M. Kim,J. L. Benovic,J.E. Krause,M G Caron,Robert J. Lefkowitz +8 more
TL;DR: Results show thatbeta ARK isozymes may regulate the function of both adenylylcyclase as well as PI-coupled receptors, and suggest a role for beta ARKIsozymes in SPR signal transduction.