Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.

Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders

Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.

Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures

Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.

Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat

Methods and apparatus for treating disorders of the ear, nose, throat or paranasal sinuses, including methods and apparatus for dilating ostia, passageways and other anatomical structures, endoscopic methods and apparatus for endoscopic visualization of structures within the ear, nose, throat or paranasal sinuses, navigation devices for use in conjunction with image guidance or navigation system and hand held devices having pistol type grips and other handpieces.

Methods and apparatus for treating disorders of the ear, nose and throat

Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.

Devices, systems and methods for treating disorders of the ear, nose and throat

β-Ethoxyvinyl polyfluoroalkyl ketones — versatile synthones in fluoroorganic chemistry

The interaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one with C-nucleophiles — organo-magnesium and -zinc compounds

The infrared spectra of two enamino-ketones containing the trifluoromethyl group, namely, 4-(N-methylamino)- 1 and 4-(N,N-dimethylamino)-1, 1, 1 -trifluorobut-3-en-2-one 2 have been investigated in a number of solvents. It has been shown the title compounds possess spectral characteristics different from those of nonfluorinated analogues. Spatial and electronic structure features of these enamino-ketones are discussed.

α,β-Unsaturated enamino-ketones with trifluoromethyl groups. Infrared spectra and structure

The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a New Protecting Reagent in Peptide Synthesis

The structures of 4N-methylamino and 4-N,N-dimethylamino-1,1,1-trifluorobut-3-en-2-one (1, 2) were solved bymeans of an analysis of 1 H, 12 H and 1 H, 13 C coupling constants, NOE measurements, 13 C, 1 H heteronuclear correlation and selective decoupling. The spectra of 1 are strongly solvent dependent. Variable-temperature experiments indicated that in these compounds the double bond character of the C-N bond is fairly pronounced and that the p-electrons from the nitrogen atom are engaged in the conjugated n-electron system. 14 N, 15 N, 17 O and 19 F chemical shifts for 1 are reported

M. G. Gorbunova

Papers

β-Ethoxyvinyl polyfluoroalkyl ketones — versatile synthones in fluoroorganic chemistry

The interaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one with C-nucleophiles — organo-magnesium and -zinc compounds

α,β-Unsaturated enamino-ketones with trifluoromethyl groups. Infrared spectra and structure

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a New Protecting Reagent in Peptide Synthesis

Conformational behaviour of some trifluoroenaminones by multinuclear magnetic resonance