M.G. Saed

TL;DR: The deterioration in oocyte quality may be caused by one or more of the following: a decrease in the antioxidant machinery by the loss of cumulus cells, the lack of scavengers for specific ROS, and/or the ability of the ROS to overcome these defenses.

TL;DR: This is the first report to show that uterine fibroids are characterized by an impaired antioxidant cellular enzymatic system and indicate a role for hypoxia in the modulation of the balance of those enzymes in fibroid and myometrial cells.

TL;DR: The data suggest that the development of cisplatin resistance tilts the balance toward a pro-oxidant state in EOC.

TL;DR: It is demonstrated that chemoresistant EOC cells are characterized by a further enhancement in oxidative stress as compared to sensitive counterparts, highlighting a potential novel mechanism of chemoresistance.

TL;DR: Investigating whether nicotinamide adenine dinucleotide phosphate oxidase (NOX), a major source of superoxide and subsequent oxidative stress, was differentially regulated in myometrium versus leiomyoma found that targeting these subunits may be beneficial for future therapeutic interventions.