Sana N. Khan

TL;DR: Investigation of the effect of CTX on metaphase II mouse oocytes obtained from treated animals, and oocytes directly exposed to increasing concentrations ofCTX and acrolein found deterioration in oocyte quality progresses in a concentration dependent manner.

TL;DR: The deterioration in oocyte quality may be caused by one or more of the following: a decrease in the antioxidant machinery by the loss of cumulus cells, the lack of scavengers for specific ROS, and/or the ability of the ROS to overcome these defenses.

TL;DR: This work provides a direct link between MPO and decreased oocyte quality and strategies to decrease MPO mediated inflammation may influence reproductive outcomes.

TL;DR: The results suggested that D-galactose and its metabolites disturbed the spindle structure and chromosomal alignment, which was associated with significant decline in oocyte cleavage and blastocyst development after in-vitro fertilization.

TL;DR: This study is the first to demonstrate direct quantitative measurement of intracellular H2O2, and its extracellular diffusion and activation of MPO as well as its impact on oocyte quality, which may help in designing more accurate treatment plans in assisted reproduction under inflammatory conditions.