M
M. Isabel Colado
Researcher at Complutense University of Madrid
Publications - 37
Citations - 3222
M. Isabel Colado is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: MDMA & Dopamine. The author has an hindex of 26, co-authored 34 publications receiving 3115 citations.
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Journal ArticleDOI
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
TL;DR: Evidence for the occurrence of MDMA-induced neurotoxic damage in human users remains equivocal, although some biochemical and functional data suggest that damage may occur in the brains of heavy users.
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The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats
Annis O. Mechan,B Esteban,B Esteban,Esther O'Shea,J. Martin Elliott,M. Isabel Colado,A. Richard Green,A. Richard Green +7 more
TL;DR: It is suggested that ecstasy‐induced hyperthermia results not from MDMA‐induced 5‐HT release, but rather from the increased release of dopamine that acts at D1 receptors, and has implications for the clinical treatment of MDMA‐ inducedhyperthermia.
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A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response.
TL;DR: It is suggested that any MDMA-induced hyperthermic response will be enhanced in hot, crowded dance club conditions and that ingesting the drug in such conditions increases the possibility of subsequent cerebral neurotoxic effect.
Journal ArticleDOI
3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose.
TL;DR: It is demonstrated that MDMA when injected directly into the brain produces 5-HT release but no neurotoxicity, suggesting that it must be metabolised peripherally in order to produce compounds that induce free radical formation and neurotoxicity in the brain.
Journal ArticleDOI
Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function.
TL;DR: It is suggested more focus be made on the actions of MDMA on dopamine neurochemistry and function to provide a better understanding of the acute and long-term consequences of using this popular recreational drug.