M.J. Solís-Heredia

TL;DR: Evidence is provided that phosphorylation of nuclear protamines is involved in the OP effects on sperm chromatin, and spermatozoa exposed during the late steps of maturation were the targets of DZN exposure.

TL;DR: Oxons were 15% to 10 times more toxic to sperm DNA than their corresponding parent compounds, at the following order: MePO>CPO=MePA>CPF >DZO>DZN, suggesting that oxon metabolites participate in OP sperm genotoxicity.

TL;DR: A wide interindividual variability of PON1 activity with a unimodal distribution is found; the range of enzymatic activity toward phenylacetate was 84.72 to 422.0 U/mL, and 88.37 to 1645.6 U/L toward paraoxon.

TL;DR: In this article, the stages of spermatogenesis susceptible to be targeted by Me-Pa exposure that impact on spermatozoa function and their ability to fertilize were investigated, and it was shown that Me-PA exposure of maturing spermatoza and sperMATocytes affects many sperm functional parameters that result in a decreased fertilizing capacity.

TL;DR: It is suggested that oxidative stress is related to Me-Pa alterations on sperm DNA integrity and cells at meiosis and epididymal maturation and 7-days post-treatment are Me- Pa targets, suggesting a potential risk of Me- pa to the offspring after transmission.