M
M. K. Church
Researcher at University of Southampton
Publications - 26
Citations - 2406
M. K. Church is an academic researcher from University of Southampton. The author has contributed to research in topics: Histamine & Tryptase. The author has an hindex of 19, co-authored 25 publications receiving 2243 citations. Previous affiliations of M. K. Church include Charité.
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Journal ArticleDOI
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.
Marcus Maurer,Karsten Weller,Carsten Bindslev-Jensen,Ana Giménez-Arnau,P. J. Bousquet,Jean Bousquet,G.W. Canonica,M. K. Church,M. K. Church,Kiran Godse,Clive Grattan,Malcolm W. Greaves,Michihiro Hide,Dimitris Kalogeromitros,Allen P. Kaplan,Sarbjit S. Saini,X J Zhu,T. Zuberbier +17 more
TL;DR: A GA2LEN task force report concluded that chronic spontaneous urticaria is a “hidden epidemic” that needs to be addressed to address the unmet clinical needs of patients.
Journal ArticleDOI
H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects
TL;DR: This review addresses novel concepts of histamine H1‐receptor function and attempts to relate them to the anti‐inflammatory effects of H1-antihistamines.
Journal ArticleDOI
Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper
M. K. Church,M. K. Church,Marcus Maurer,F. E. R. Simons,Carsten Bindslev-Jensen,P. Van Cauwenberge,Jean Bousquet,S. T. Holgate,T. Zuberbier +8 more
TL;DR: Risk of first‐generation H1‐antihistamines: a GA2LEN position paper and implications for clinical practice are outlined.
Journal ArticleDOI
TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.
TL;DR: Findings which both locate immunoreactive TNF α to nasal mast cells and identify its release following in vivo exposure to allergen, provide evidence for mast cells as an important source of this cytokine in patients with allergic rhinitis.
Journal ArticleDOI
Production and characterization of monoclonal antibodies specific for human mast cell tryptase.
TL;DR: Human mast cell tryptase was purified from lung tissue by high salt extraction, ammonium sulphate precipitation, octyl Sepharose and heparin‐agarose chromatography and three new monoclonal antibodies were produced which were specific fortryptase in indirect ELISAs, immunoenzymatic overlay in crossed immunoelectrophoresis and by Western blotting.