M
M. M. Heath
Researcher at Hammersmith Hospital
Publications - 7
Citations - 2502
M. M. Heath is an academic researcher from Hammersmith Hospital. The author has contributed to research in topics: Receptor & Hypothalamus. The author has an hindex of 7, co-authored 7 publications receiving 2403 citations.
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Journal ArticleDOI
A role for glucagon-like peptide-1 in the central regulation of feeding
M. D. Turton,Donal O'Shea,I. Gunn,S. A. Beak,C. M. B. Edwards,K Meeran,S. J. Choi,G. M. Taylor,M. M. Heath,P.D. Lambert,John P.H. Wilding,David M. Smith,M. A. Ghatei,J. Herbert,S.R. Bloom +14 more
TL;DR: It is reported here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats, and this findings suggest that central GLp-1 is a new physiological mediator of satiety.
Journal ArticleDOI
Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.
Min Seon Kim,M. Rossi,S. Abusnana,D. Sunter,David G.A. Morgan,Caroline J. Small,C. M. B. Edwards,M. M. Heath,Sarah Stanley,L. J. Seal,J. R. Bhatti,David M. Smith,M. A. Ghatei,S.R. Bloom +13 more
TL;DR: It is indicated that the hypothalamic nuclei expressing MC4R vary in their sensitivity to Agrp and alpha-MSH with regard to their effect on feeding, and that the PVN, DMN, and MPO were the areas with the greatest response to A Grp and NDP- MSH.
Journal ArticleDOI
Neuropeptide Y induced feeding in the rat is mediated by a novel receptor.
Donal O'Shea,David G.A. Morgan,Karim Meeran,C. M. B. Edwards,M. D. Turton,S. J. Choi,M. M. Heath,I. Gunn,G. M. Taylor,Jane K. Howard,Chloe I Bloom,Caroline J. Small,O. Haddo,J. J. Ma,W. Callinan,David M. Smith,M. A. Ghatei,S.R. Bloom +17 more
TL;DR: The novel fragment NPY(3–36) is as effective at stimulating food intake as the classical Y1 analogue [Pro34]-NPY but bound to the Y1 receptor with only 1/20th of the affinity of NPY and failed to inhibit adenylyl cyclase through this receptor.
Journal ArticleDOI
Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.
S. A. Beak,M. M. Heath,Caroline J. Small,David G.A. Morgan,M. A. Ghatei,A D Taylor,J C Buckingham,S.R. Bloom,David M. Smith +8 more
TL;DR: GLP-1 levels in the hypothalami of 48-h-fasted male rats showed a decrease, indicating a possible association of the satiety factor with the low luteinizing hormone levels in animals with a negative energy balance.
Journal ArticleDOI
Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release.
Caroline J. Small,David G.A. Morgan,Karim Meeran,M. M. Heath,I. Gunn,C. M. B. Edwards,James Gardiner,G. M. Taylor,James D. Hurley,M. Rossi,Anthony P. Goldstone,Donal O'Shea,David M. Smith,M. A. Ghatei,S.R. Bloom +14 more
TL;DR: A series of analogues of the hypothalamic neuropeptide Y (NPY) were synthesized as a ligand with low Y1 and Y2 receptor affinity as mentioned in this paper.