M. Rocio A. Carrera

TL;DR: It is suggested that long-term cannabinoid administration alters CRF function in the limbic system of the brain, in a manner similar to that observed with other drugs of abuse, and also induces neuroadaptive processes that may result in future vulnerability to drug dependence.

TL;DR: It is suggested that immunopharmacotherapy may offer a promising means to treat cocaine abuse by aiding in the prevention of relapse and the ability of antibodies to block the reinforcing effects of the drug.

TL;DR: A method is presented for engineering filamentous bacteriophage to display cocaine-binding proteins on its surface that sequester cocaine in the brain and suggests the application of this protein-based treatment for other drug abuse syndromes.

TL;DR: The results support the potential clinical value of immunopharmacotherapy for nicotine addiction in the context of tobacco cessation programs and show much less nicotine was found in the brains of immunized rats.

TL;DR: The present study supports the hypothesis that dependence-induction by morphine-pellet implant in rats resulted in increased sensitivity to very small naloxone doses, as measured by changes in HSA, and suggests that opiate dependence, as Measurement of changes in sensitivity to n aloxone, is a continuum which can contribute to the motivational state of drug-seeking.