M
M Tanaka
Researcher at Cold Spring Harbor Laboratory
Publications - 10
Citations - 1807
M Tanaka is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Transcription factor & POU domain. The author has an hindex of 10, co-authored 10 publications receiving 1804 citations.
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Journal ArticleDOI
Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation
M Tanaka,Winship Herr +1 more
TL;DR: Oct-2 displays a unique phosphorylation pattern that is absent from molecules lacking one or the other activation domain, suggesting the activation domains have a role in inducing protein phosphorylated.
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The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16
Seth Stern,M Tanaka,Winship Herr +2 more
TL;DR: The herpes simplex virus transactivator VP16 par-ticipates in the formation of a multiprotein-DNA complex with the ubiquitous octamer-motif-binding factor Oct-1, indicating that this structure is an ancient target for protein-protein interactions mediating transcriptional control.
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Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter
TL;DR: It is shown that Oct-1 and Oct-2 can differentially activate transcription not through DNA binding specificity but instead through the use of promoter-selective activation domains.
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A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIB fraction
TL;DR: It is shown that the TFIIIB fraction required for RNA polymerase III transcription contains two separable components, one of which is a TBP-containing complex that may correspond to B-TFIID.
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Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.
TL;DR: In the context of the U2 promoter, the octamer motif defines a new class of RNA polymerase II enhancer elements, which bind transcription factors that trans-activate gene expression by a different mechanism than the general mechanism mentioned above.