M
M. Van De Winkel
Researcher at Vrije Universiteit Brussel
Publications - 18
Citations - 1668
M. Van De Winkel is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Islet & B cell. The author has an hindex of 12, co-authored 18 publications receiving 1623 citations.
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Journal ArticleDOI
Interplay of nutrients and hormones in the regulation of insulin release.
TL;DR: The concept that the potent in vivo insulin-releasing action of glucose and leucine is not only dependent on their fuel capacity in pancreatic B cells but also on the concurrent cAMP levels is strongly supported.
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A new in vitro model for the study of pancreatic A and B cells.
TL;DR: A method is developed for the preparation of single, pure, and viable rat pancreatic A and B cells in numbers sufficient for in vitro analysis and is expected to contribute to the understanding of the regulation of glucagon and insulin release.
Journal ArticleDOI
Glucose-induced insulin release depends on functional cooperation between islet cells
TL;DR: This study provides direct support for the concept that the microanatomy of the islet creates the anatomical basis for functional cooperation between islet cells and hence for an appropriate glucose-induced insulin release.
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Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity.
TL;DR: It is concluded that intercellular differences in metabolic responsiveness result in functional heterogeneity of the pancreatic B cell population.
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Pancreatic B cells possess defense mechanisms against cell-specific toxicity.
TL;DR: Physiologic compounds such as glucose and nicotinamide were found to stimulate islet B cells to counteract the damaging effects of B-cell toxic conditions, and it is conceivable that the events involved in this protection are implicated in the pathogenesis and/or prevention of insulin-dependent diabetes.