A metal-free, simple, and scalable method for the synthesis of the amides (III), (V), (VII), and (X) is developed from commercially available or easily synthesized starting materials.

Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

Considering the importance of the development of powerful green catalysts and the omnipresence of amide bonds in natural and synthetic compounds, we report here on reactions between alcohols and amines for amide bond formation in which heterogeneous gold and gold/iron, -nickel, or -cobalt nanoparticles are used as catalysts and molecular oxygen is used as terminal oxidant. Two catalysts show excellent activity and selectivity, depending on the type of alcohols used. A wide variety of alcohols and amines, including aqueous ammonia and amino acids, can be used for the amide synthesis. Furthermore, the catalysts can be recovered and reused several times without loss of activity.

Powerful amide synthesis from alcohols and amines under aerobic conditions catalyzed by gold or gold/iron, -nickel or -cobalt nanoparticles.

Metal‐Free Oxidative Carbon‐Heteroatom Bond Formation Through C–H Bond Functionalization

A Pd-catalyzed aerobic oxidative C–H nitration and acylation of arenes with simple and readily available tert-butyl nitrite (TBN) and toluene as the radical precursors has been developed. Molecular oxygen is employed as the terminal oxidant and oxygen source to initiate the active radical reactants. Many different directing groups such as pyridine, pyrimidine, pyrazole, pyridol, pyridylketone, oxime, and azo groups can be employed in these novel transformations. The PdII/PdIV catalytic cycle through a radical process is the most likely pathway for these oxidative C–H nitration and acylation reactions.

Aerobic Oxidation of PdII to PdIV by Active Radical Reactants: Direct C–H Nitration and Acylation of Arenes via Oxygenation Process with Molecular Oxygen

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.

CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines

Oxidative Amidation of Aldehydes and Alcohols with Primary Amines Catalyzed by KI-TBHP

This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.

Highly Efficient One‐Pot Synthesis of 2‐Substituted Quinazolines and 4H‐Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite

Catalytic oxidative conversion of alcohols, aldehydes and amines into nitriles using KI/I2–TBHP system

The direct oxidation of aromatic primary amines to the corresponding nitro compounds selectively in 47–98% yields has been achieved by using potassium iodide as catalyst and tert-butyl hydroperoxide as the external oxidant. The present catalytic system works well for both electron-rich and electron-poor substrates.

M. Venkateshwar

Papers

Oxidative Amidation of Aldehydes and Alcohols with Primary Amines Catalyzed by KI-TBHP

Highly Efficient One‐Pot Synthesis of 2‐Substituted Quinazolines and 4H‐Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite

Catalytic oxidative conversion of alcohols, aldehydes and amines into nitriles using KI/I2–TBHP system

Selective Oxidation of Aromatic Amines to Nitro Derivatives using Potassium Iodide‐tert‐Butyl Hydroperoxide Catalytic System

Mild and efficient oxy-iodination of alkynes and phenols with potassium iodide and tert-butyl hydroperoxide