Mac B. Robinson

TL;DR: It is shown that astrocytes subjected to hyperthermia upregulate Hsp/c70 in addition to intracellular signaling components including activated forms of extracellular‐signal‐regulated kinase (ERK1/2), Akt, and c‐jun N‐terminal kinase/stress activated protein Kinase (JNK/SAPK).

TL;DR: The administration of recombinant human Hsp70 was effective at increasing lifespan, delaying symptom onset, preserving motor function and prolonging MN survival and results suggest rhHsp70 may delay disease progression in the G93A SOD1 mouse via a yet to be identified peripheral mechanism.

TL;DR: It is demonstrated that, although endogenous expression of heat shock protein 70 (HSP70) did not change during trophic factor deprivation, application of e-rhHsp70 (exogenous recombinant human Hsp70) promoted motoneuron survival and indicated that the source of this factor is instrumental in determining its trophics function.

TL;DR: The IL6R coding SNP rs2228145 (Asp(358)Ala) is a potential modifier of lung function in subjects with asthma and might identify subjects at risk for more severe asthma.

TL;DR: It is found that muscle cells produce and secrete ProBDNF, and data is provided to suggest that proBDNF regulates MN PCD during development in vivo.