抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

We present an all atom potential energy function for the simulation of proteins and nucleic acids. This work is an extension of the CH united atom function recently presented by S.J. Weiner et al. J. Amer. Chem. Soc., 106, 765 (1984). The parameters of our function are based on calculations on ethane, propane, n−butane, dimethyl ether, methyl ethyl ether, tetrahydrofuran, imidazole, indole, deoxyadenosine, base paired dinucleoside phosphates, adenine, guanine, uracil, cytosine, thymine, insulin, and myoglobin. We have also used these parameters to carry out the first general vibrational analysis of all five nucleic acid bases with a molecular mechanics potential approach.

An all atom force field for simulations of proteins and nucleic acids.

We report the high capacity and rate capability of mesoporous Co3O4 nanowire (NW) arrays as anodes in Li ion batteries. At a current of 1C, the NW arrays maintain a capacity of 700 mAh/g after 20 discharge/charge cycles. When the current is increased to 50C, 50% of the capacity can be retained. With their ease of large area synthesis and superior electrochemical properties, these Co3O4 NW arrays will be interesting for practical Li ion batteries.

Mesoporous Co3O4 nanowire arrays for lithium ion batteries with high capacity and rate capability.

Structure, energetics, and dynamics of the nucleic Acid base pairs: nonempirical ab initio calculations.

The infrared spectra of matrix-isolated adenine and its 15N isotopomers with 15N at the N(9) or N(7) positions have been studied. The experimentally observed IR spectra were compared with the spectra predicted at the DFT(B3-LYP)/6-31G(d,p) level. This method was also used to calculate molecular parameters (rotational constants, dipole moments) of both N(9)H and N(7)H tautomers of adenine. The agreement between experimental and theoretical spectral positions, intensities, and isotopic shifts of the IR bands is good. That allows for reliable assignment of the IR spectra and for conclusion that the amino-N(9)H tautomer of adenine strongly dominates in low-temperature matrices.

Molecular Structure and Infrared Spectra of Adenine. Experimental Matrix Isolation and Density Functional Theory Study of Adenine 15N Isotopomers

Author Institution: Institute of Physics, Polish Academy of Sciences; Department of Chemistry, University of Florida

Matrix isolation studies of nucleic acid constituents. i. infrared spectra of uracil monomers

Prototropic tautomerism of a model system of 2-hydroxypyridine/2(1H)-pyridinone has been investigated in low-temperature inert matrices and in the gas phase. The ratio of tautomer concentrations, [hydroxy]:[oxo], for the 2-pyridinone sample deposited in Ar or N 2 matrices was estimated as 2.80:1 and 2.99:1, respectively. A similar ratio of tautomers was observed in the gas phase. The matrix and gas-phase infrared spectra of2-hydroxypyridine and 2(1H)-pyridinone are reported

Maciej J. Nowak

Papers

Molecular Structure and Infrared Spectra of Adenine. Experimental Matrix Isolation and Density Functional Theory Study of Adenine 15N Isotopomers

Matrix isolation studies of nucleic acid constituents. i. infrared spectra of uracil monomers

Matrix isolation IR spectroscopy of tautomeric systems and its theoretical interpretation: 2-hydroxypyridine/2(1H)-pyridinone

Matrix isolation studies of cytosine: The separation of the infrared spectra of cytosine tautomers

Thiouracils. 2. Tautomerism and infrared spectra of thiouracils. Matrix-isolation and ab initio studies