抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

We present an all atom potential energy function for the simulation of proteins and nucleic acids. This work is an extension of the CH united atom function recently presented by S.J. Weiner et al. J. Amer. Chem. Soc., 106, 765 (1984). The parameters of our function are based on calculations on ethane, propane, n−butane, dimethyl ether, methyl ethyl ether, tetrahydrofuran, imidazole, indole, deoxyadenosine, base paired dinucleoside phosphates, adenine, guanine, uracil, cytosine, thymine, insulin, and myoglobin. We have also used these parameters to carry out the first general vibrational analysis of all five nucleic acid bases with a molecular mechanics potential approach.

An all atom force field for simulations of proteins and nucleic acids.

We report the high capacity and rate capability of mesoporous Co3O4 nanowire (NW) arrays as anodes in Li ion batteries. At a current of 1C, the NW arrays maintain a capacity of 700 mAh/g after 20 discharge/charge cycles. When the current is increased to 50C, 50% of the capacity can be retained. With their ease of large area synthesis and superior electrochemical properties, these Co3O4 NW arrays will be interesting for practical Li ion batteries.

Mesoporous Co3O4 nanowire arrays for lithium ion batteries with high capacity and rate capability.

Structure, energetics, and dynamics of the nucleic Acid base pairs: nonempirical ab initio calculations.

Infrared matrix isolation and ab initio studies of 3(2H)-pyridazinone and photoproduced 3-hyroxypyridazine

Theoretical and matrix-isolation experimental study of the infrared spectra of 5-azauracil and 6-azauracil

A series of molecules with a common structural feature of a five-membered quasi-ring closed by an intramolecular hydrogen bond OH···OC interaction has been studied. In the series the compounds differ by the size of the main-ring which varies from 4 to 7 atoms. The molecules were isolated in low-temperature matrices and investigated by IR spectroscopy. The strength of the OH···OC interaction, depending on the size of the main ring, was spectroscopically revealed by the position of the infrared bands due to the stretching and torsional vibrations of the OH group. All the intermediate cases from very weak hydrogen-bond-like interaction to medium strength hydrogen bonding were observed, indicating that the strict boundary between the cases “hydrogen bond” and “no hydrogen bond” does not exist. This experimental conclusion is supported by theoretical
calculations, performed at HF/6-31++G**, MP2/6-31 + G* and DFT(B3LYP)/6-31++G** levels.

Maciej J. Nowak

Papers

Infrared matrix isolation and ab initio studies of 3(2H)-pyridazinone and photoproduced 3-hyroxypyridazine

Theoretical and matrix-isolation experimental study of the infrared spectra of 5-azauracil and 6-azauracil

IR spectral and theoretical characterization of intramolecular hydrogen bonds closing five-membered rings

Infrared matrix isolation studies on tautomerism of cytosine and isocytosine methyl-derivatives

Infrared matrix isolation and ab initio studies of 4-oxopyrimidine; separation of the spectra of tautomers based on the phototautomeric effect