Maddalena Mastrogiacomo

TL;DR: In this paper, the effects of in vitro expansion on BMSC pluripotentiality, proliferative ability, and bone-forming efficiency in vivo were investigated, and the lifespan and differentiation kinetics of five of these clones were determined.

TL;DR: The present study shows the long-term durability of bone regeneration achieved by a bone engineering approach and proposes the use of culture-expanded osteoprogenitor cells in conjunction with porous bioceramics as a real and significant improvement in the repair of critical-sized long bone defects.

TL;DR: It is shown that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional VN and neuronal systems of ex-vivo mouse spinal cord at scales spanning from millimeters to hundreds of nanometers, with nor contrast agent nor sectioning and neither destructive sample-preparation.

TL;DR: It is reported that fibroblast growth factor 2 (FGF-2)-supplemented bone marrow stromal cell primary cultures display an early increase in telomere size followed by a gradual decrease, whereas in control cultures telomeres length steadily decreases with increasing population doublings.

TL;DR: It is concluded that FGF2 maintains human BMSC in an immature state allowing their 'in vitro' expansion, and strongly supported the formation of bone as well as of cartilage.