L
Lucio Luzzatto
Researcher at Muhimbili University of Health and Allied Sciences
Publications - 302
Citations - 18952
Lucio Luzzatto is an academic researcher from Muhimbili University of Health and Allied Sciences. The author has contributed to research in topics: Paroxysmal nocturnal hemoglobinuria & Population. The author has an hindex of 66, co-authored 289 publications receiving 17398 citations. Previous affiliations of Lucio Luzzatto include University College Hospital, Ibadan & College of Health Sciences, Bahrain.
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Journal ArticleDOI
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Peter Hillmen,Neal S. Young,Jörg Schubert,Robert A. Brodsky,Gérard Socié,Petra Muus,Alexander Röth,Jeff Szer,Modupe O. Elebute,Ryotaro Nakamura,Paul Browne,Antonio M. Risitano,Anita Hill,Hubert Schrezenmeier,Chieh Lin Fu,Jaroslaw P. Maciejewski,Scott A. Rollins,Christopher F. Mojcik,Russell P. Rother,Lucio Luzzatto +19 more
TL;DR: Eculizumab is an effective therapy for PNH and Clinically significant improvements were found in the quality of life, as measured by scores on the Functional Assessment of Chronic Illness Therapy-Fatigue instrument and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire.
Journal ArticleDOI
Natural history of paroxysmal nocturnal hemoglobinuria.
TL;DR: PNH is a chronic disorder that curtails life, and a spontaneous long-term remission can occur, which must be taken into account when considering potentially dangerous treatments, such as bone marrow transplantation.
Journal ArticleDOI
Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
Charles J. Parker,Mitsuhiro Omine,Stephen J. Richards,Junichi Nishimura,Monica Bessler,Russell E. Ware,Peter Hillmen,Lucio Luzzatto,Neal S. Young,Taroh Kinoshita,Wendell F. Rosse,Gérard Socié +11 more
TL;DR: The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria are hemolytic anemia, marrow failure, and thrombophilia.
Journal ArticleDOI
Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
Chad May,Stefano Rivella,John Callegari,Glenn Heller,Karen M. L. Gaensler,Lucio Luzzatto,Michel Sadelain +6 more
TL;DR: It is shown that the use of recombinant lentiviruses enables efficient transfer and faithful integration of the human β-globin gene together with large segments of its locus control region, which should be of therapeutic benefit in patients with severe defects in haemoglobin production.
Journal ArticleDOI
Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress
TL;DR: It is concluded that G6PD activity is dispensable for pentose synthesis, but is essential to protect cells against even mild oxidative stress.