Magdalena Hagn

TL;DR: These findings establish the existence of human B cells with a regulatory phenotype in solid tumor infiltrates, where they may contribute to the suppression of antitumor immune responses and stimulate novel diagnostic and cell therapeutic approaches to better manage human cancer as well as autoimmune and graft-versus-host pathologies.

TL;DR: These findings suggest that GrB-secreting B cells support the early antiviral immune response against viruses with endosomal entry pathways, thereby counteracting overwhelming viral replication at the beginning of an infection until virus-specific T cells from draining lymph nodes arrive at the site of infection.

TL;DR: It is shown that in the absence of CD40L, CD4+ T cell‐derived IL‐21 induces differentiation of B cells into granzyme B (GzmB)‐secreting cytotoxic cells, which may have a role in early cellular immune responses including tumor immunosurveillance before fully activated, antigen‐specific cytot toxic T cells are on the spot.

TL;DR: A better understanding of the role that GrB-secreting B cells are playing in the immune system may allow for the development and improvement of novel immunotherapeutic approaches against infectious, autoimmune and malignant diseases.

TL;DR: It is demonstrated that IL‐21 and GzmB serum levels are highly correlated in subjects with systemic lupus erythematosus (SLE) and that freshly isolated CD5+ SLE B cells constitutively express GZmB and the data suggest thatIL‐21 may have disease‐modifying characteristics by inducing GzMB inCD5+ B cells and by suppressing their expansion.