D
Dorit Fabricius
Researcher at University of Ulm
Publications - 38
Citations - 1104
Dorit Fabricius is an academic researcher from University of Ulm. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 24 publications receiving 811 citations.
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Journal ArticleDOI
Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
Stefanie Lindner,Karen Dahlke,Kai Sontheimer,Magdalena Hagn,Christof Kaltenmeier,Thomas F. E. Barth,Thamara Beyer,Frank Reister,Dorit Fabricius,Ramin Lotfi,Oleg Lunov,Gerd Ulrich Nienhaus,Thomas Simmet,Rolf Kreienberg,Peter Möller,Hubert Schrezenmeier,Bernd Jahrsdörfer +16 more
TL;DR: These findings establish the existence of human B cells with a regulatory phenotype in solid tumor infiltrates, where they may contribute to the suppression of antitumor immune responses and stimulate novel diagnostic and cell therapeutic approaches to better manage human cancer as well as autoimmune and graft-versus-host pathologies.
Journal ArticleDOI
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Bernd Jahrsdörfer,Angelika Vollmer,Sue E. Blackwell,Julia Maier,Kai Sontheimer,Thamara Beyer,Birgit Mandel,Oleg Lunov,Kyrylo Tron,G. Ulrich Nienhaus,G. Ulrich Nienhaus,Thomas Simmet,Klaus-Michael Debatin,George J. Weiner,Dorit Fabricius +14 more
TL;DR: It is demonstrated that human plasmacytoid dendritic cells can be an abundant source of GrB and that such GrB(+) pDCs potently suppress T-cell proliferation in a GrB-dependent, perforin-independent manner, a process reminiscent of regulatory T cells.
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Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21
Magdalena Hagn,Elisabeth Schwesinger,Verena Ebel,Kai Sontheimer,Julia Maier,Thamara Beyer,Tatiana Syrovets,Yves Laumonnier,Dorit Fabricius,Thomas Simmet,Bernd Jahrsdörfer +10 more
TL;DR: These findings suggest that GrB-secreting B cells support the early antiviral immune response against viruses with endosomal entry pathways, thereby counteracting overwhelming viral replication at the beginning of an infection until virus-specific T cells from draining lymph nodes arrive at the site of infection.
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Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help.
Magdalena Hagn,Kai Sontheimer,Karen Dahlke,Sabine Brueggemann,Christof Kaltenmeier,Thamara Beyer,S Hofmann,Oleg Lunov,Thomas F. E. Barth,Dorit Fabricius,Kyrylo Tron,Gerd Ulrich Nienhaus,Gerd Ulrich Nienhaus,Thomas Simmet,Hubert Schrezenmeier,Bernd Jahrsdörfer +15 more
TL;DR: It is shown that in the absence of CD40L, CD4+ T cell‐derived IL‐21 induces differentiation of B cells into granzyme B (GzmB)‐secreting cytotoxic cells, which may have a role in early cellular immune responses including tumor immunosurveillance before fully activated, antigen‐specific cytot toxic T cells are on the spot.
Journal ArticleDOI
Prostaglandin E2 Inhibits IFN-α Secretion and Th1 Costimulation by Human Plasmacytoid Dendritic Cells via E-Prostanoid 2 and E-Prostanoid 4 Receptor Engagement
Dorit Fabricius,Marina Neubauer,Birgit Mandel,Catharina Schütz,Andreas Viardot,Angelika Vollmer,Bernd Jahrsdörfer,Klaus-Michael Debatin +7 more
TL;DR: The data suggest that PGE2 and certain PG analogs should be evaluated as a novel and inexpensive treatment approach for patients with SLE and other IFN-α–dependent, Th1-driven autoimmune diseases.