M
Majed Halwani
Researcher at King Saud bin Abdulaziz University for Health Sciences
Publications - 32
Citations - 961
Majed Halwani is an academic researcher from King Saud bin Abdulaziz University for Health Sciences. The author has contributed to research in topics: Pseudomonas aeruginosa & Tobramycin. The author has an hindex of 10, co-authored 28 publications receiving 769 citations. Previous affiliations of Majed Halwani include Laurentian University & National Guard Health Affairs.
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Journal ArticleDOI
Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa
TL;DR: The data suggest that liposome-entrapped antibiotics could successfully resolve infections caused by antibiotic-resistant P. aeruginosa through an enhanced mechanism of drug entry into the bacterial cells.
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Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains.
TL;DR: Infiltration of polymyxin B into a resistant strain of Pseudomonas aeruginosa was higher following its administration as a liposomal formulation as compared to its conventional form and the combination of free drug and plain liposomes had an antibacterial activity similar to that of free antibiotic.
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Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa
Majed Halwani,B. Yebio,Zacharias E. Suntres,Zacharias E. Suntres,Misagh Alipour,Ali Azghani,Abdelwahab Omri +6 more
TL;DR: The results clearly indicate that the Lipo-Ga-GEN formulation is more effective than gentamicin alone in eradicating antibiotic-resistant P. aeruginosa isolates growing in a planktonic or biofilm community.
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Bactericidal efficacy of liposomal aminoglycosides against Burkholderia cenocepacia.
TL;DR: A liposomal antibiotic formulation composed of 1,2-distearoyl-sn-glycero-3-phosphocholine and cholesterol (molar ratio 2:1) to overcome B. cenocepacia's resistance to commonly used aminoglycosidic antibiotics is developed.
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Bismuth-thiol incorporation enhances biological activities of liposomal tobramycin against bacterial biofilm and quorum sensing molecules production by Pseudomonas aeruginosa.
Majed Halwani,Stéphanie Hebert,Zacharias E. Suntres,Zacharias E. Suntres,Robert M. Lafrenie,Robert M. Lafrenie,Ali Azghani,Abdelwahab Omri +7 more
TL;DR: Co-encapsulation of bismuth-thiol metal with tobramycin in liposome improves its antimicrobial activities in vitro and is able to penetrate CF sputum.