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Aseem Kumar
Researcher at Laurentian University
Publications - 103
Citations - 12979
Aseem Kumar is an academic researcher from Laurentian University. The author has contributed to research in topics: Septic shock & Sepsis. The author has an hindex of 41, co-authored 99 publications receiving 11849 citations. Previous affiliations of Aseem Kumar include University of Toronto & University of Science and Technology of China.
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Journal ArticleDOI
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.
Anand Kumar,Daniel Roberts,Kenneth E. Wood,Bruce Light,Joseph E. Parrillo,Satendra Sharma,Robert Suppes,Daniel Feinstein,Sergio Zanotti,Leo Taiberg,David A. Gurka,Aseem Kumar,Mary Cheang +12 more
TL;DR: Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock.
Journal ArticleDOI
Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock
Anand Kumar,Anand Kumar,Paul Ellis,Yaseen M. Arabi,Dan Roberts,Bruce Light,Joseph E. Parrillo,Peter Dodek,Gordon Wood,Aseem Kumar,David Simon,Cheryl Peters,Muhammad Ahsan,Dan Chateau +13 more
TL;DR: Efforts to increase the frequency of the appropriateness of initial antimicrobial therapy must be central to efforts to reduce the mortality of patients with septic shock.
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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yi-Li Yang,Luiz F. L. Reis,Jovan Pavlovic,Adriano Aguzzi,R. Schafer,Aseem Kumar,Bryan R.G. Williams,Michel Aguet,Charles Weissmann +8 more
TL;DR: In embryo fibroblasts from Pkr knockout mice, the induction of type I IFN as well as the activation of NF‐kappa B by pIC, were strongly impaired but restored by priming with IFN, suggesting a pIC‐responsive system independent of PKR is induced by IFN.
Journal ArticleDOI
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B
Aseem Kumar,Jaharul Haque,Judith Lacoste,John Hiscott,Bryan R.G. Williams,Bryan R.G. Williams +5 more
TL;DR: Direct evidence is presented that PKR can phosphorylate I kappa B-alpha (MAD-3) and activate NF-kappa B DNA binding activity in vitro, and it is shown that dsRNA induces an unusual phosphorylated form of I k Kappa B- alpha.
Journal ArticleDOI
Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases
Aseem Kumar,Mairead Commane,Thomas W. Flickinger,Curt M. Horvath,Curt M. Horvath,George Stark Stark,George Stark Stark +6 more
TL;DR: Variant STAT1 proteins carrying point mutations that inactivate domains required for STAT dimer formation nevertheless restored protease expression and sensitivity to apoptosis, indicating that the functions of STAT1 required for these activities are different from those that mediate induced gene expression.