M
Makoto Osaki
Researcher at Nagasaki University
Publications - 163
Citations - 2810
Makoto Osaki is an academic researcher from Nagasaki University. The author has contributed to research in topics: Quantitative computed tomography & Bone mineral. The author has an hindex of 27, co-authored 148 publications receiving 2417 citations.
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Journal ArticleDOI
Characterization of Individuals with Sacroiliac Joint Bridging in a Skeletal Population: Analysis of Degenerative Changes in Spinal Vertebrae
Takeshi Imamura,Kazunobu Saiki,Keishi Okamoto,Junichiro Maeda,Hiroaki Matsuo,Tetsuaki Wakebe,Keiko Ogami,Yoshitaka Manabe,Hironobu Koseki,Masato Tomita,Atsushi Tagami,Makoto Osaki,Hiroyuki Shindo,Toshiyuki Tsurumoto +13 more
TL;DR: SIB and marginal osteophyte formation in vertebral bodies could coexist in a skeletal population of men by analyzing the degenerative changes in their whole vertebral column and comparing them with the controls.
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Effect of surface roughness of biomaterials on Staphylococcus epidermidis adhesion.
Itaru Yoda,Hironobu Koseki,Masato Tomita,Takayuki Shida,Hidehiko Horiuchi,Hideyuki Sakoda,Makoto Osaki +6 more
TL;DR: The results suggest that minimum level of roughness affecting initial bacterial adherence activity differs according to the type of biomaterial used, and that even a surface roughness of below 30 nm Ra in Oxinium, Ti-6Al-4 V and SUS316L can promote bacterial adhesion.
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Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc
Noboru Yatsugi,Tomoo Tsukazaki,Makoto Osaki,Takehiko Koji,Shunichi Yamashita,Hiroyuku Shindo +5 more
TL;DR: The results suggest that the degree of chondrocytes in RA more readily undergo apoptosis than those in OA, and that the expression of p53 and c-myc proteins in ISNEL-positive areas may reflect the involvement of these proteins in the apoptotic process in articular chondroses in inflammatory arthritis.
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Early Staphylococcal Biofilm Formation on Solid Orthopaedic Implant Materials: In Vitro Study
Hironobu Koseki,Akihiko Yonekura,Takayuki Shida,Itaru Yoda,Hidehiko Horiuchi,Yoshitomo Morinaga,Katsunori Yanagihara,Hideyuki Sakoda,Makoto Osaki,Masato Tomita +9 more
TL;DR: Results suggest that surface properties, such as hydrophobicity or the low surface free energy of Co-Cr-Mo, may have some influence in inhibiting or delaying the two-dimensional expansion of biofilm on surfaces with a similar degree of smoothness.
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Dexamethasone inhibition of TGFβ-induced cell growth and type II collagen mRNA expression through ERK-integrated AP-1 activity in cultured rat articular chondrocytes
Youichi Miyazaki,Tomoo Tsukazaki,Yasuhiro Hirota,Akihiko Yonekura,Makoto Osaki,Hiroyuki Shindo,Shunichi Yamashita +6 more
TL;DR: The results indicate that DEX suppressed TGF beta-induced chondrocyte proliferation and type II collagen expression, probably through selective inhibition of ERK integrated AP-1 activation.