M
Makoto Shimizu
Researcher at University of Texas Southwestern Medical Center
Publications - 1
Citations - 80
Makoto Shimizu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Response element & Starvation response. The author has an hindex of 1, co-authored 1 publications receiving 63 citations.
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Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Rucha Patel,Angie L. Bookout,Lilia Magomedova,Bryn M. Owen,Giulia P. Consiglio,Makoto Shimizu,Yuan Zhang,David J. Mangelsdorf,Steven A. Kliewer,Carolyn L. Cummins +9 more
TL;DR: FGF21 and GCs regulate each other's production in a feed-forward loop and it is suggested that this provides a mechanism for bypassing negative feedback on the hypothalamic-pituitary-adrenal axis to allow sustained gluconeogenesis during starvation.