Yuan Zhang

TL;DR: Transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling, raising the possibility that FGF 21 can be used to extend lifespan in other species.

TL;DR: These studies further distinguish the roles of LXRα and β and support a growing body of evidence that LXRs function as key regulators of lipid metabolism and are anti-atherogenic.

TL;DR: In this paper, it was shown that the presence of an unsaturated bond in the side chain of the sterol was necessary and sufficient for activity, with the C-24 unsaturated cholesterol precursor sterols desmosterol and zy mosterol exerting the largest effects.

TL;DR: It is shown that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys, raising the possibility that F GF21 administration could affect nutrient preference and other reward behaviors in humans.

TL;DR: Observations suggest that therapeutic strategies that bypass the liver or limit the activation of hepatic LXRs should still be beneficial for the treatment of cardiovascular disease.