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David J. Mangelsdorf
Researcher at University of Texas Southwestern Medical Center
Publications - 261
Citations - 81271
David J. Mangelsdorf is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Receptor & Nuclear receptor. The author has an hindex of 123, co-authored 255 publications receiving 76172 citations. Previous affiliations of David J. Mangelsdorf include Howard Hughes Medical Institute & Salk Institute for Biological Studies.
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Journal ArticleDOI
The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.
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The RXR heterodimers and orphan receptors
TL;DR: The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented.
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Identification of a Nuclear Receptor for Bile Acids
Makoto Makishima,Arthur Y. Okamoto,Joyce J. Repa,Hua Tu,R. Marc Learned,Alvin Luk,Mitchell V. Hull,Kevin D. Lustig,David J. Mangelsdorf,Bei Shan +9 more
TL;DR: Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor, which demonstrates a mechanism by which bile acid transcriptionally regulate their biosynthesis and enterohepatic transport.
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Nuclear receptors and lipid physiology: opening the X-files.
TL;DR: Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Richard A. Heyman,David J. Mangelsdorf,Jacqueline A. Dyck,Jacqueline A. Dyck,Robert B. Stein,Gregor Eichele,Ronald M. Evans,Ronald M. Evans,Christina Thaller +8 more
TL;DR: An experimental approach is reported that has identified 9-cis RA as an RXR ligand, up to 40-fold more potent than all-trans RA in transfection assays and binds with high affinity.