M
Malcolm D. Walkinshaw
Researcher at University of Edinburgh
Publications - 271
Citations - 10414
Malcolm D. Walkinshaw is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cyclophilin & Allosteric regulation. The author has an hindex of 56, co-authored 269 publications receiving 9737 citations. Previous affiliations of Malcolm D. Walkinshaw include Purdue University & University of Dundee.
Papers
More filters
Journal ArticleDOI
Insights into antifolate resistance from malarial DHFR-TS structures.
Jirundon Yuvaniyama,Penchit Chitnumsub,Sumalee Kamchonwongpaisan,Jarunee Vanichtanankul,Worachart Sirawaraporn,Paul Taylor,Malcolm D. Walkinshaw,Yongyuth Yuthavong +7 more
TL;DR: The crystal structures of PfDHFR-TS from the wild type and the quadruple drug-resistant mutant (V1/S) strains, in complex with a potent inhibitor WR99210, as well as the resistant double mutant with the antimalarial pyrimethamine, reveal features for overcoming resistance.
Journal ArticleDOI
Order-disorder transition for a bacterial polysaccharide in solution. A role for polysaccharide conformation in recognition between Xanthomonas pathogen and its plant host
TL;DR: The ordered form of Xanthomonas species of Gram-negative bacteria can bind co-operatively to certain plant cell wall polysaccharides in a way that suggests a role in the colonization of the plant host by the bacterial pathogen.
Journal ArticleDOI
MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG
Kok Lian Ho,Iain W. McNae,Lars Schmiedeberg,Robert J. Klose,Adrian Bird,Malcolm D. Walkinshaw +5 more
TL;DR: X-ray analysis of a methylated DNA-MBD cocrystal reveals that the methyl groups make contact with a predominantly hydrophilic surface that includes tightly bound water molecules, which suggests that MeCP2 recognizes hydration of the major groove of methylatedDNA rather than cytosine methylation per se.
Journal ArticleDOI
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
Jörg Kallen,Claus Spitzfaden,Mauro G. M. Zurini,Gerhard Wider,Hans Widmer,Kurt Wüthrich,Malcolm D. Walkinshaw +6 more
TL;DR: The X-ray crystal structure of human recombinant cyclophilin complexed with a tetrapeptide is reported and the identification, by nuclear magnetic resonance spectroscopy, of the specific binding site for cyclosporin A is identified.
Journal ArticleDOI
Conformations and interactions of pectins. II. Models for junction zones in pectinic acid and calcium pectate gels.
TL;DR: These model-building studies provide plausible visualizations of two different kinds of junction zones that may exist in pectic gels.