Malcolm J. Kavarana

TL;DR: An 800-million-member DNA-encoded library in which small molecules are covalently attached to an encoding oligonucleotide is reported, assembled by a combination of chemical and enzymatic synthesis, and interrogated by affinity selection.

TL;DR: In this article, a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag was proposed. But this method is not suitable for the use of binary codes.

TL;DR: In this article, the authors present compounds which modulate the activity of the SI P1 receptor, and the use of these compounds for treating conditions associated with signaling through the S 1 P 1 receptor.

TL;DR: In this article, a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag was proposed, which was used to identify a compound.

TL;DR: In the design of potent and selective sphingosine-1-phosphate receptor agonists, two series of molecules based on phenylamide and phenylimidazole analogs of FTY-720 demonstrated dose responsive lymphopenia, when administered orally.